Background and objectives: Previous investigations have shown that physical activity can improve insulin sensitivity and body composition by reducing the concentration of inflammatory biomarkers. The study aimed at evaluating effects of eight weeks of resistance training and high-intensity interval training on adropin, blood glucose markers, and body composition in overweight females. Methods: sixteen overweight females (mean age: 30 ±,4. 3 years and body mass index= 29 ±,2. 6 kg/m ) were randomly assigned to a resistance training group (n=8) and a high-intensity interval training group (n=8). Participants in both groups trained three times a week for eight weeks. Body composition and serum level of blood markers were determined at baseline and after the last training session. Results: Body mass, body fat percentage, and waist-hip ratio decreased significantly in both groups (p<0. 05). VO2max 2 significantly increased in both groups, while the changes in the resistance training group were greater than in the high-intensity interval training group (p<0. 05). Insulin and HOMA-IR concentrations decreased significantly in the resistance training group (p<0. 05). Conclusion: Eight weeks of both training procedures could significantly decrease body composition markers. However, the training duration was not sufficient to alter fating blood sugar or adropin concentrations.